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1.
Clin Biomech (Bristol, Avon) ; 108: 106067, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37633176

RESUMO

BACKGROUND: Patellofemoral instability influences the gait pattern and activity level in adolescents. However, gait biomechanics to cope with recurrent patella instability and its relation to radiological findings has hardly been studied. METHODS: We retrospectively analyzed kinematic and kinetic gait analysis data, magnetic resonance images and X-ray of 32 adolescents with unilateral recurrent patellofemoral instability aged 12 to 18 years. Subjects were assigned to 3 groups based on their sagittal knee moment in the loading response and mid stance phase. Kinematic and kinetic differences among the groups were analyzed using a one-way ANOVA. A multinomial logistic regression model provided a further analysis of the relationship between gait biomechanics and MRI as well as X-ray parameters. FINDINGS: All three groups showed different characteristics of the knee kinematics during loading response and single stance: while the patella-norm-loading group showed a slightly reduced knee flexion (p ã€ˆ0,01), the patella-unloading group kept the knee nearly extended (p < 0,01) and patella-overloading group showed an increased knee flexion (p = 0,01) compared to the other groups. In single stance the patella-overloading group maintained increased knee flexion (p < 0,01) compared to patella-unloading group and patella-norm-loading group. None of the radiological parameters proved to be related to gait patterns. INTERPRETATION: The paper describes different gait coping strategies and their clinical relevance in subjects with patellofemoral instability. However, we did not find any relation of gait biomechanics to skeletal morphology.


Assuntos
Marcha , Instabilidade Articular , Articulação Patelofemoral , Adolescente , Humanos , Marcha/fisiologia , Análise da Marcha , Estudos Retrospectivos , Fenômenos Biomecânicos , Articulação Patelofemoral/fisiopatologia , Instabilidade Articular/fisiopatologia , Masculino , Feminino
2.
J Sports Sci Med ; 22(1): 36-43, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36876176

RESUMO

The Balance Error Scoring System (BESS), a subjective examiner-based assessment, is often employed to assess postural balance in individuals with chronic ankle instability (CAI); however, inertial sensors may enhance the detection of balance deficits. This study aimed to compare the BESS results between the CAI and healthy groups using conventional BESS scores and inertial sensor data. The BESS test (six conditions: double-leg, single-leg, and tandem stances on firm and foam surfaces, respectively) was performed for the CAI (n = 16) and healthy control (n = 16) groups with inertial sensors mounted on the sacrum and anterior shank. The BESS score was calculated visually by the examiner by counting postural sway as an error based on the recorded video. The root mean square for resultant acceleration (RMSacc) in the anteroposterior, mediolateral, and vertical directions was calculated from each inertial sensor affixed to the sacral and shank surfaces during the BESS test. The mixed-effects analysis of variance and unpaired t-test were used to assess the effects of group and condition on the BESS scores and RMSacc. No significant between-group differences were found in the RMSacc of the sacral and shank surfaces, and the BESS scores (P > 0.05), except for the total BESS score in the foam condition (CAI: 14.4 ± 3.7, control: 11.7 ± 3.4; P = 0.039). Significant main effects of the conditions were found with respect to the BESS scores and RMSacc for the sacral and anterior shank (P < 0.05). The BESS test with inertial sensors can detect differences in the BESS conditions for athletes with CAI. However, our method could not detect any differences between the CAI and healthy groups.


Assuntos
Articulação do Tornozelo , Instabilidade Articular , Equilíbrio Postural , Humanos , Aceleração , Atletas , Doença Crônica , Instabilidade Articular/diagnóstico , Instabilidade Articular/fisiopatologia , Equilíbrio Postural/fisiologia , Coluna Vertebral , Dispositivos Eletrônicos Vestíveis
3.
J Orthop Surg Res ; 17(1): 173, 2022 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-35313904

RESUMO

BACKGROUND: While decreased hip abductor strength, functional performance, and self-reported instability scores have all been shown in association with CAI, any sex difference in the relationship between these indicators is unclear. This study was to determine whether sex differences are present in the relationship between these indicators in individuals with CAI. METHODS: Thirty-two women and twenty-nine men with unilateral CAI took part. Hip abductor strength and functional performance were respectively assessed using a hand-held dynamometer and the figure-8-hop test. All 61 participants scored the Cumberland Ankle Instability Tool (CAIT) for self-reported ankle instability. Independent sample t-tests and correlation analysis were conducted. RESULTS: Normalized hip abductor strength and functional performance measures for females were lower than for males. The self-reported ankle instability CAIT score, where higher values represent less instability, was significantly and positively correlated with both normalized hip abductor strength (p = 0.003) and functional performance (p = 0.001) on the affected side in females, but not in males (p = 0.361 and p = 0.192 respectively). CONCLUSIONS: Sex differences were observed in that there were significant relationships between normalized hip abductor strength, functional performance, and CAIT scores in female CAI participants, but not males, suggesting that CAI evaluation and rehabilitation strategies should be sex-specific. HIGHLIGHTS: In females with CAI, hip abductor strength and functional performance showed significant relationships with self-reported instability scores. Correspondingly, in clinical practice with individuals with CAI, evaluation criteria may be formulated according to these observed sex differences. Sex differences should be factored into the evaluation and treatment of CAI individuals. Hip strength assessment should be employed with CAI individuals. Hip strengthening and functional hopping may be recommended for the rehabilitation of CAI, especially in female patients.


Assuntos
Traumatismos do Tornozelo , Articulação do Tornozelo , Instabilidade Articular , Tornozelo , Traumatismos do Tornozelo/fisiopatologia , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Desempenho Físico Funcional , Treinamento de Força , Caracteres Sexuais
4.
Arthroscopy ; 38(3): 750-751, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35248228

RESUMO

A large Hill-Sachs lesion that engages the glenoid rim and predisposes to recurrent anterior instability confers a substantial management challenge. Arthroscopic remplissage, either in isolation or combined with anterior labral repair, gives the arthroscopic surgeon a tool to stabilize the shoulder without reverting to more extensive open procedures or bone block reconstructions. In arthroscopic remplissage, the posterior capsule and infraspinatus are sutured into the humeral defect to limit such engagement between the HilleSachs lesion and the glenoid rim. The double-pulley technique using 2 transtendon anchors makes arthroscopic remplissage technically simpler, and potentially more reproducible, than earlier techniques. As we refine remplissage techniques, we need to further explore issues such as the optimal distance between the 2 anchors (and hence the resultant tendon bridge) as this distance-along with the pliability of the tendon-potentially determines how much compression against the bone can be achieved. Furthermore, as remplissage techniques are proven to be effective in restoring shoulder stability and conferring successful clinical function, there is even more need for high-quality comparative studies to define their role versus that of more extensive open stabilization procedures. Mechanistic studies are also needed to define the fill-effect versus the possible check-rein and neuromuscular control activation components of remplissage.


Assuntos
Lesões de Bankart , Instabilidade Articular , Luxação do Ombro , Articulação do Ombro , Artroscopia/métodos , Lesões de Bankart/patologia , Humanos , Instabilidade Articular/fisiopatologia , Luxação do Ombro/fisiopatologia , Luxação do Ombro/cirurgia , Articulação do Ombro/fisiopatologia
5.
Sci Rep ; 12(1): 610, 2022 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-35022508

RESUMO

The modified Broström procedure (MBP) is an initial treatment for symptomatic chronic ankle instability (CAI) patients. This study aimed to compare the proprioception and neuromuscular control ability of both affected and unaffected ankles at the time of return to sports after MBP for patients with scores of normal controls. 75 individuals (40 who underwent MBP, 35 normal controls) participated. The dynamic balance test scores were significantly higher in the affected ankle of the patients than in the controls (1.5 ± 0.6° vs. 1.1 ± 0.4°, p < 0.003). The time to peak torque for dorsiflexion (60.8 ± 13.9 ms vs. 52.2 ± 17.5 ms, p < 0.022) and eversion (68.9 ± 19.1 ms vs. 59.3 ± 21.1 ms, p < 0.043) was significantly delayed in the affected ankle of the patients than in the controls. The dynamic balance test and time to peak torque in CAI patients remained significantly reduced at the time of return-to-sport after MBP. Clinicians and therapists should be aware of potential deficits in proprioception and neuromuscular control when determining the timing of return to sports after MBP.


Assuntos
Articulação do Tornozelo/cirurgia , Instabilidade Articular/cirurgia , Procedimentos Ortopédicos/reabilitação , Propriocepção , Volta ao Esporte/fisiologia , Adulto , Articulação do Tornozelo/fisiopatologia , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Estudos Retrospectivos , Adulto Jovem
6.
Med Sci Sports Exerc ; 54(1): 28-37, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34431830

RESUMO

PURPOSE: Proprioceptive feedback is crucial for motor control and stabilization of the shoulder joint in everyday life and sports. Shoulder dislocation causes anatomical and proprioceptive feedback damage that contributes to subsequent dislocations. Previous recurrent anterior shoulder instability (RSI) studies did not investigate functional neuroplasticity related to proprioception of the injured shoulder. Thus, we aimed to study the differences in neuroplasticity related to motor control between patients with RSI and healthy individuals, using functional magnetic resonance imaging, and assess the effects of peripheral proprioceptive deficits due to RSI on CNS activity. METHODS: Using passive shoulder motion and voluntary shoulder muscles contraction tasks, we compared the CNS correlates of proprioceptive activity between patients having RSI (n = 13) and healthy controls (n = 12) to clarify RSI pathophysiology and the effects of RSI-related peripheral proprioceptive deficits on CNS activity. RESULTS: Decreased proprioception-related brain activity indicated a deficient passive proprioception in patients with RSI (P < 0.05 family-wise error, cluster level). Proprioceptive afferent-related right cerebellar activity significantly negatively correlated with the extent of shoulder damage (P = 0.001, r = -0.79). Functional magnetic resonance imaging demonstrated abnormal motor control in the CNS during voluntary shoulder muscles contraction. CONCLUSION: Our integrated analysis of peripheral anatomical information and brain activity during motion tasks can be used to investigate other orthopedic diseases.


Assuntos
Instabilidade Articular/fisiopatologia , Plasticidade Neuronal/fisiologia , Propriocepção/fisiologia , Lesões do Ombro/fisiopatologia , Adulto , Encéfalo/diagnóstico por imagem , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Adulto Jovem
7.
Sports Biomech ; 21(4): 447-459, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34511029

RESUMO

Limited evidence exists comparing running biomechanics between individuals with chronic ankle instability (CAI) and those who fully recover (copers). The purpose of this study was to simultaneously analyse running gait kinematics, kinetics, and surface electromyography (sEMG) between ankle sprain copers and individuals with CAI. Twenty-six (13 CAI, 13 Coper) recreationally active females participated and ran shod on an instrumented treadmill at 2.68 m/s. We assessed lower extremity kinematics and kinetics and sEMG amplitude for the fibularis longus, tibialis anterior, medial gastrocnemius, and gluteus medius muscles. Ten consecutive strides from the beginning of the trial were analysed using statistical parametric mapping (SPM) independent t-test. The CAI group had significantly more ankle inversion during 0-6%, 42-53%, and 96-100% of the running stride cycle compared to the coper group. At initial contact (0%), the CAI group was in an inverted ankle position (5.9°±6.8°) and the coper group was in an everted ankle position (-3.2°±5.5°; p = 0.01, d = 1.5). There were no significant differences identified for any other outcome measures. Increased ankle inversion during the swing phase leading into the loading phase is concerning because the ankle is in an open packed position and inversion is a primary mechanism of injury for sustaining a lateral ankle sprain.


Assuntos
Traumatismos do Tornozelo , Marcha , Instabilidade Articular , Corrida , Traumatismos do Tornozelo/fisiopatologia , Articulação do Tornozelo/fisiopatologia , Fenômenos Biomecânicos , Feminino , Humanos , Instabilidade Articular/fisiopatologia
8.
Sci Rep ; 11(1): 19782, 2021 10 05.
Artigo em Inglês | MEDLINE | ID: mdl-34611207

RESUMO

The aim of this study was to evaluate the joint contact area of the dominant side and that of the non-dominant side without valgus instability in symptomatic pitchers. Ten symptomatic elbow medial ulnar collateral ligament (UCL) deficient baseball pitchers participated in this study. Computed tomography (CT) data from the dominant and non-dominant elbows were obtained with and without elbow valgus stress. The CT imaging data of each elbow joint were reconstructed using a 3D reconstruction software package, and the radiocapitellar and ulnohumeral joint contact areas were calculated. The center of the contact area and the translation from the position without stress to the position with valgus stress were also calculated. With elbow valgus stress, the contact area changed, and the center of the radiocapitellar joint contact area translated significantly more laterally in the dominant elbow than in the non-dominant elbow (p = 0.0361). In addition, the center of the ulnohumeral joint contact area translated significantly more posteriorly in the dominant elbow than in the non-dominant elbow (p = 0.0413). These changes in contact areas could be the reason for cartilage injury at the posterior trochlea in pitchers with UCL deficiency.


Assuntos
Atletas , Beisebol , Articulação do Cotovelo/patologia , Articulação do Cotovelo/fisiopatologia , Instabilidade Articular/diagnóstico , Instabilidade Articular/fisiopatologia , Adulto , Fenômenos Biomecânicos , Articulação do Cotovelo/diagnóstico por imagem , Humanos , Instabilidade Articular/etiologia , Masculino , Sistema Musculoesquelético , Estresse Mecânico , Tomografia Computadorizada por Raios X , Adulto Jovem
9.
Sci Rep ; 11(1): 20369, 2021 10 13.
Artigo em Inglês | MEDLINE | ID: mdl-34645864

RESUMO

We aimed to analyze the differences in static (including conventional and modified [single-leg heel-raise balance]) and dynamic postural stability and muscle endurance between patients with chronic ankle instability (CAI) and healthy controls, and to determine the reliability and usefulness of the single-leg heel-raise balance test in patients with CAI. In total, 26 patients with CAI and 26 healthy controls were enrolled. Postural stability was assessed using a postural stabilometry system. Muscle endurance was measured in dorsiflexion and plantarflexion using an isokinetic device. Modified static postural stability (P < 0.001) and dynamic postural stability (P < 0.001) were significantly poorer in the affected ankles of patients with CAI than in the controls. Plantarflexion endurance was significantly lower in the affected ankles of the patients with CAI than in the controls (P = 0.023). Modified static postural stability significantly correlated with plantarflexion endurance in both groups (CAI group: r = - 0.470, P = 0.015; healthy controls group: r = - 0.413, P = 0.036). Plantarflexion endurance was a significant risk factor for modified static postural stability in both the CAI group (R2 = 0.221, P = 0.015) and healthy controls (R2 = 0.170, P = 0.036). Given the reliability of the modified static postural stability test, clinicians and therapists should consider using it to assess improvements in postural stability and muscle endurance in patients with CAI before and after rehabilitation.


Assuntos
Articulação do Tornozelo/fisiopatologia , Instabilidade Articular/fisiopatologia , Equilíbrio Postural , Adulto , Doença Crônica , Feminino , Humanos , Instabilidade Articular/terapia , Masculino , Modalidades de Fisioterapia
10.
Rheumatol Int ; 41(10): 1785-1794, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34398260

RESUMO

Diagnosing hypermobile Ehlers-Danlos syndrome (hEDS) remains challenging, despite new 2017 criteria. Patients not fulfilling these criteria are considered to have hypermobile spectrum disorder (HSD). Our first aim was to evaluate whether patients hEDS were more severely affected and had higher prevalence of extra-articular manifestations than HSD. Second aim was to compare their outcome after coordinated physical therapy. Patients fulfilling hEDS/HSD criteria were included in this real-life prospective cohort (November 2017/April 2019). They completed a 16-item Clinical Severity Score (CSS-16). We recorded bone involvement, neuropathic pain (DN4) and symptoms of mast cell disorders (MCAS) as extra-articular manifestations. After a standardized initial evaluation (T0), all patients were offered the same coordinated physical therapy, were followed-up at 6 months (T1) and at least 1 year later (T2), and were asked whether or not their condition had subjectively improved at T2. We included 97 patients (61 hEDS, 36 HSD). Median age was 40 (range 18-73); 92.7% were females. Three items from CSS-16 (pain, motricity problems, and bleeding) were significantly more severe with hEDS than HSD. Bone fragility, neuropathic pain and MCAS were equally prevalent. At T2 (20 months [range 18-26]) 54% of patients reported improvement (no difference between groups). On multivariable analysis, only family history of hypermobility predicted (favorable) outcome (p = 0.01). hEDS and HDS patients showed similar disease severity score except for pain, motricity problems and bleeding, and similar spectrum of extra-articular manifestations. Long-term improvement was observed in > 50% of patients in both groups. These results add weight to a clinical pragmatic proposition to consider hEDS/HSD as a single entity that requires the same treatments.


Assuntos
Síndrome de Ehlers-Danlos/diagnóstico , Instabilidade Articular/diagnóstico , Adulto , Idoso , Síndrome de Ehlers-Danlos/fisiopatologia , Síndrome de Ehlers-Danlos/terapia , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Instabilidade Articular/terapia , Masculino , Pessoa de Meia-Idade , Gravidade do Paciente , Modalidades de Fisioterapia , Estudos Prospectivos
11.
Biomed Res Int ; 2021: 7549750, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34307669

RESUMO

The anterolateral ligament (ALL) has been suggested as an important secondary knee restrain on the dynamic laxity in anterior cruciate ligament- (ACL-) deficient knees. Nevertheless, its kinematical contribution to the pivot-shift (PS) phenomenon has not been clearly and objectively defined, and noninvasive sensor technology could give a crucial contribution in this direction. The aim of the present study was to quantify in vitro the PS phenomenon in order to investigate the differences between an ACL-deficient knee and an ACL+ALL-deficient knee. Ten fresh-frozen paired human cadaveric knees (n = 20) were included in this controlled laboratory study. Intact, ACL-deficient, and ACL+ALL-deficient knees were subjected to a manual PS test quantified by a noninvasive triaxial accelerometer (KiRA, OrthoKey). Kinematic data (i.e., posterior acceleration of the tibial lateral compartment) were recorded and compared among the three statuses. Pairwise Student's t-test was used to compare the single groups (p < 0.05). Intact knees, ACL-deficient knees, and ACL+ALL-deficient knees showed an acceleration of 5.3 ± 2.1 m/s2, 6.3 ± 2.3 m/s2, and 7.8 ± 2.1 m/s2, respectively. Combined sectioning of ACL and ALL resulted in a statistically significant acceleration increase compared to both the intact state (p < 0.01) and the ACL-deficient state (p < 0.01). The acceleration increase determined by isolated ACL resection compared to the intact state was not statistically significant (p > 0.05). The ALL sectioning increased the rotatory laxity during the PS after ACL sectioning as measured through a user-friendly, noninvasive triaxial accelerometer.


Assuntos
Lesões do Ligamento Cruzado Anterior/fisiopatologia , Instabilidade Articular/fisiopatologia , Articulação do Joelho/fisiopatologia , Rotação , Acelerometria , Idoso , Idoso de 80 Anos ou mais , Cadáver , Humanos , Masculino , Amplitude de Movimento Articular
12.
J Sports Sci Med ; 20(2): 373-390, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34211331

RESUMO

This review aimed to investigate characteristics of muscle activation and ground reaction force (GRF) patterns in patients with ankle instability (AI). Relevant studies were sourced from PubMed, CINAHL, SPORTDiscus, and Web of Science through December 2019 for case-control study in any laboratory setting. Inclusion criteria for study selection were (1) subjects with chronic, functional, or mechanical instability or recurrent ankle sprains; (2) primary outcomes consisted of muscle activation of the lower extremity and GRF during landing; and (3) peer-reviewed articles with full text available, including mean, standard deviation, and sample size, to enable data reanalysis. We evaluated four variables related to landing task: (1) muscle activation of the lower extremity before landing, (2) muscle activation of the lower extremity during landing, (3) magnitude of GRF, and (4) time to peak GRF. The effect size using standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for these variables to make comparisons across studies. Patients with AI had a lower activation of peroneal muscles before landing (SMD = -0.63, p < 0.001, CI = -0.95 to -0.31), greater peak vertical GRF (SMD = 0.21, p = 0.03, CI = 0.01 to 0.40), and shorter time to peak vertical GRF (SMD = -0.51, p < 0.001, CI = -0.72 to -0.29) than those of normal subjects during landing. There was no significant difference in other muscle activation and GRF components between the patients with AI and normal subjects (p > 0.05). Altered muscle activation and GRF before and during landing in AI cases may contribute to both recurrent ankle and ACL injuries and degenerative change of articular.


Assuntos
Articulação do Tornozelo/fisiopatologia , Instabilidade Articular/fisiopatologia , Extremidade Inferior/fisiologia , Músculo Esquelético/fisiologia , Traumatismos do Tornozelo/fisiopatologia , Lesões do Ligamento Cruzado Anterior/fisiopatologia , Humanos , Extremidade Inferior/lesões , Exercício Pliométrico , Recidiva , Fatores de Risco , Entorses e Distensões/fisiopatologia , Análise e Desempenho de Tarefas
13.
J Sci Med Sport ; 24(12): 1240-1244, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34281769

RESUMO

OBJECTIVES: The deficits in sensory pathways caused by peripheral edema, pain, and inflammation of the damaged ligaments may induce maladaptive changes within the central nervous system. The purpose of this study was to determine whether patients with lateral ankle instability (LAI) exhibit morphological differences of brain grey matter when compared with healthy controls, and then assess the relationships between the observed differences and the characteristics of patients. DESIGN: Cross-sectional. METHODS: Thirty patients with LAI and 32 healthy controls without LAI underwent MRI scans using anatomical T1 sequences. A voxel-wise general linear model was used to compare the grey matter volume throughout the whole brain between patients and controls. Linear regression analyses were performed for the grey matter volume within the significant clusters to assess their relationship with age, sex, the existence of acute injury, pain level, sports activity level, and the duration of LAI within the patient group. RESULTS: The grey matter volume of a cluster within the cerebellar vermis (Vermis_4_5 in automated anatomical labeling template) was significantly reduced in patients with LAI (Gaussian Random Field corrections with two-tailed p-cluster < 0.05 and p-voxel < 0.001). Multivariate linear regression analysis revealed that the duration of LAI tended to be passively associated with the grey matter volume of this LAI-related vermal cluster (p = 0.092). CONCLUSIONS: Participants with LAI exhibited a reduced grey matter volume of a cluster within the cerebellar vermis compared with participants without LAI, and the degree of volume reduction tended to be positively associated with the duration of LAI.


Assuntos
Articulação do Tornozelo/fisiopatologia , Substância Cinzenta/diagnóstico por imagem , Substância Cinzenta/fisiopatologia , Instabilidade Articular/fisiopatologia , Imageamento por Ressonância Magnética , Plasticidade Neuronal/fisiologia , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Tamanho do Órgão , Adulto Jovem
14.
Am J Med Genet A ; 185(12): 3754-3761, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34331416

RESUMO

Dysautonomia is a recognized manifestation in patients with joint hypermobility (JH) disorders. Symptoms can be highly debilitating and commonly include physical deconditioning and poor aerobic fitness. In this study, the prevalence of dysautonomia, range of associated symptoms, patient-reported physical activity levels, and echocardiographic features were assessed retrospectively in a cohort of 144 patients (94% female) with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorder (HSD). Echocardiographic parameters of left ventricular size and function were compared between patients with and without dysautonomia as well as to reported values from healthy controls. Dysautonomia was identified in 65% of female and 44% of male subjects and was associated with a high burden of symptomatology, most commonly exercise intolerance (78%). Exercise capacity was limited by dysautonomia, often postural symptoms, in half of all patients. We observed a reduction in physical activity following the onset or significant flare of hEDS/HSD, most strikingly noting the proportion of dysautonomic patients with sedentary lifestyle, which increased from 44% to 85%. JH-related dysautonomia was associated with smaller cardiac chamber sizes, consistent with the previous reports in positional orthostatic tachycardia syndrome. Dysautonomia is prevalent in patients with hEDS/HSD, and exercise intolerance is a key feature and leads to drastic decline in physical activity. Unfavorable cardiac geometry may underlie dysautonomia symptoms and may be due to cardiac atrophy in the setting of aerobic deconditioning.


Assuntos
Síndrome de Ehlers-Danlos/fisiopatologia , Exercício Físico/efeitos adversos , Instabilidade Articular/fisiopatologia , Disautonomias Primárias/fisiopatologia , Adulto , Atrofia/complicações , Atrofia/diagnóstico por imagem , Atrofia/fisiopatologia , Ecocardiografia , Síndrome de Ehlers-Danlos/complicações , Síndrome de Ehlers-Danlos/diagnóstico por imagem , Exercício Físico/fisiologia , Feminino , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/fisiopatologia , Humanos , Instabilidade Articular/complicações , Instabilidade Articular/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Disautonomias Primárias/complicações , Disautonomias Primárias/diagnóstico por imagem , Estudos Retrospectivos
15.
Sci Rep ; 11(1): 15385, 2021 07 28.
Artigo em Inglês | MEDLINE | ID: mdl-34321559

RESUMO

To determine the functional recovery, active reincorporation, and anteroposterior and rotational stability of patients undergoing anterior cruciate ligament (ACL) reconstruction using arthroscopy techniques with simple-bundle (SB) or double-bundle (DB). The following databases were searched: PubMed, Embase (Elsevier platform), the Cochrane Central Register of Controlled Trials (Wiley platform), Web of Science, and CINAHL. Level I and II studies involving anterior cruciate ligament arthroscopy were included in the search. Records were screened by title and abstract and assessed the risk of bias of selected studies. Meta-analyses using RevMan 5.3 software were conducted on the following outcomes: knee functionality, objective measurements of knee stability, rotational knee stability and knee anterior stability, sports reincorporation, and subjective assessments. Twenty-four studies of patients undergoing ACL reconstruction were included in the qualitative and quantitative synthesis (1707 patients) for Lysholm score, Subjective International Knee Documentation Committee (IKDC) score, Tegner score, KT-1000/2000, Lachman test, Objective IKDC score, and Pivot-Shift test. A return to pre-injury level showed a significant decrease in the Lysholm score (mean difference, - 0.99; 95% CI - 1.71 to - 0.40; P = 0.007) and Tegner score (mean difference, - 0.07; 95% CI, - 0.13 to - 0.01; P = 0.02) at DB reconstruction, similar to the knee functionality outcome of the subjective IKDC score (mean difference - 1.42; 95% CI - 2.46 to - 0.38; P = 0.007). There is no clear or significant difference in clinical stability and knee function or in sports incorporation with the true difference occurring in the subjective assessment.


Assuntos
Lesões do Ligamento Cruzado Anterior/reabilitação , Reconstrução do Ligamento Cruzado Anterior/normas , Ligamento Cruzado Anterior/diagnóstico por imagem , Traumatismos do Joelho/reabilitação , Ligamento Cruzado Anterior/fisiopatologia , Lesões do Ligamento Cruzado Anterior/fisiopatologia , Artroscopia/normas , Humanos , Instabilidade Articular/fisiopatologia , Instabilidade Articular/reabilitação , Traumatismos do Joelho/terapia , Articulação do Joelho/fisiopatologia , Recuperação de Função Fisiológica/fisiologia
16.
Biomed Res Int ; 2021: 6664864, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34124258

RESUMO

BACKGROUND: The hypermobile type of Ehlers-Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue mainly characterized by joint hypermobility. Patients with hEDS suffer joint pain, in particular low back pain, commonly resistant to drug therapy. The aim of this research was to evaluate a neurocognitive rehabilitation approach based not only on the motion and function recovery but also on the pain management. METHODS: In this nonrandomized clinical trial, eighteen hEDS patients (4 males and 14 females) with mean age 21 years (range 13-55) were recruited and evaluated before and after three months of rehabilitation treatment. RESULTS: The outcome scores showed significant statistical results after treatment in reducing pain symptoms (numerical rating scale, P = 0.003; McGill (total score), P = 0.03), fatigue (fatigue severity scale, P = 0.03), fear of movement (Tampa scale, P = 0.003), and pain-associated disability (Oswestry disability index, P = 0.03). CONCLUSION: The clinical results observed in our study seem to confirm the role of a specific neurocognitive rehabilitation program in the chronic pain management in the Ehlers-Danlos syndrome; the rehabilitation treatment should be tailored on patient problems and focused not only in the recovery of movement but also on pain perception.


Assuntos
Dor Crônica , Síndrome de Ehlers-Danlos , Terapia por Exercício , Instabilidade Articular , Dor Lombar , Manejo da Dor , Adolescente , Adulto , Dor Crônica/fisiopatologia , Dor Crônica/reabilitação , Síndrome de Ehlers-Danlos/fisiopatologia , Síndrome de Ehlers-Danlos/reabilitação , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Instabilidade Articular/reabilitação , Dor Lombar/fisiopatologia , Dor Lombar/reabilitação , Masculino , Pessoa de Meia-Idade
17.
Am J Med Genet A ; 185(10): 3153-3160, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34159694

RESUMO

Biallelic mutations in B3GALT6, coding for a galactosyltransferase involved in the synthesis of glycosaminoglycans (GAGs), have been associated with various clinical conditions, causing spondyloepimetaphyseal dysplasia with joint laxity type 1 (SEMDJL1 or SEMDJL Beighton type), Al-Gazali syndrome (ALGAZ), and a severe progeroid form of Ehlers-Danlos syndrome (EDSSPD2). In the 2017 Ehlers-Danlos syndrome (EDS) classification, Beta3GalT6-related disorders were grouped in the spondylodysplastic EDSs together with spondylodysplastic EDSs due to B4GALT7 and SLC39A13 mutations. Herein, we describe a patient with a previously unreported homozygous pathogenic B3GALT6 variant resulting in a complex phenotype more severe than spondyloepimetaphyseal dysplasia with joint laxity type 1, and having dural ectasia and aortic dilation as additionally associated features, further broadening the phenotypic spectrum of the Beta3GalT6-related syndromes. We also document the utility of repeating sequencing in patients with uninformative exomes, particularly when performed by using "first generations" enrichment capture methods.


Assuntos
Galactosiltransferases/genética , Instabilidade Articular/genética , Osteocondrodisplasias/genética , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/patologia , Adolescente , Adulto , Segmento Anterior do Olho/anormalidades , Segmento Anterior do Olho/patologia , Osso e Ossos/anormalidades , Osso e Ossos/patologia , Criança , Pré-Escolar , Síndrome de Ehlers-Danlos/genética , Síndrome de Ehlers-Danlos/patologia , Feminino , Homozigoto , Humanos , Instabilidade Articular/diagnóstico , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/patologia , Instabilidade Articular/fisiopatologia , Mutação/genética , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/diagnóstico por imagem , Osteocondrodisplasias/fisiopatologia , Fenótipo , Adulto Jovem
18.
Am J Med Genet A ; 185(10): 2986-2994, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34145717

RESUMO

Physiotherapy techniques are regularly prescribed in the hypermobile type Ehlers-Danlos syndrome (hEDS) and they are appreciated by the patients. The objective of this systematic review was to investigate the effect of the different physiotherapy techniques related to the children and adult patients with hEDS. PubMed, SPORTDiscus, Cochrane Library, PEDro, Scopus, and Embase databases were analyzed from inception to April 2020. Characteristics of the studies (authors), patients (sample size, sex, age, Beighton score), and nonpharmacological treatment (length of the program, number of session, duration of the session, and type of intervention), and the results with the dropout rate were extracted. From the 1045 retrieved references, 6 randomized controlled trial with a sample size ranging from 20 to 57 patients were included in the systematic review. There was a huge heterogeneity in the interventions. The durations of the program were from 4 to 8 weeks. Pain or proprioception demonstrated significant improvements in the intervention group regardless of the type of intervention. A benefit of the inspiratory muscle training was observed on functional exercise capacity. The quality of life was systematically improved. Physiotherapy benefits on proprioception and pain in patients with hEDS even if robust randomized control studies are missing.


Assuntos
Síndrome de Ehlers-Danlos/terapia , Instabilidade Articular/terapia , Dor/fisiopatologia , Modalidades de Fisioterapia , Síndrome de Ehlers-Danlos/fisiopatologia , Exercício Físico , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Manejo da Dor/tendências , Qualidade de Vida
19.
Jt Dis Relat Surg ; 32(2): 437-445, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34145822

RESUMO

OBJECTIVES: This study aims to compare the outcomes of patients undergoing a single anterior portal or a standard two-portal arthroscopic procedure for Bankart repair. PATIENTS AND METHODS: Between January 2015 and March 2018, a total of 71 consecutive patients (53 males and 18 females; mean age: 33.3±10.3 years; range, 17 to 56 years) who underwent arthroscopic Bankart repair with a minimum two-year follow-up period were included. The patients were divided into two groups according to the arthroscopic technique used: single anterior portal group (Group 1, n=32) and standard two-portal group (Group 2, n=39). Demographic and surgical characteristics of the patients were recorded. Pre- and postoperative clinical and functional outcomes were evaluated using the external rotation degree, as well as Visual Analog Scale (VAS), American Shoulder and Elbow Surgeons (ASES), University of California at Los Angeles (UCLA) Shoulder Rating Scale, Constant-Murley Score (CMS), Oxford Shoulder Instability Score (OSIS), and Rowe scores. The clinical and functional outcomes and revision rates were compared between the groups. RESULTS: The mean follow-up was 32.0±7.4 months in Group 1 and 38.0±13.4 months in Group 2 (p=0.222). Good-to-excellent postoperative functional and clinical outcomes were achieved in both groups at the final follow-up, compared to baseline (p<0.001 for all). No significant difference was observed in the postoperative outcomes including daily sports activity, VAS, ASES, UCLA Shoulder Rating Scale, CMS, OSIS, and Rowe scores, and external rotation restriction degrees between the groups (p=0.270, p=0.190, p=0.313, p=0.248, p=0.125, p=0.203, p=0.318, p=0.083, respectively). The operative time in Group 1 was significantly lower than that in Group 2 (60.3±8.3 vs. 71.4±7.2, respectively; p=0.001). Four patients (5.6%) experienced recurrent dislocation with no significant difference between the groups (p=0.622). No significant complications occurred in the peri- or postoperative period. Fifty-eight (81.7%) patients returned to their preoperative sports activity level. The mean time to return to sports was 7.2±1.7 months. CONCLUSION: Good-to-excellent clinical and functional outcomes can be obtained after arthroscopic Bankart repair, regardless of the use of a single or two anterior working portals. However, the single-portal technique is associated with reduced the operative time, compared to two-portal technique.


Assuntos
Artroscopia/métodos , Instabilidade Articular/cirurgia , Luxação do Ombro/cirurgia , Articulação do Ombro/fisiopatologia , Adolescente , Adulto , Artroscopia/efeitos adversos , Feminino , Seguimentos , Humanos , Instabilidade Articular/complicações , Instabilidade Articular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Duração da Cirurgia , Medição da Dor , Complicações Pós-Operatórias/etiologia , Amplitude de Movimento Articular , Recidiva , Volta ao Esporte , Rotação , Luxação do Ombro/complicações , Luxação do Ombro/fisiopatologia , Articulação do Ombro/cirurgia , Dor de Ombro/etiologia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
20.
J Nippon Med Sch ; 88(2): 133-137, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33980758

RESUMO

BACKGROUND: Diagnosis and treatment of traumatic posterior instability of the shoulder have not been described in detail. The author investigated surgical outcomes for traumatic posterior shoulder joint instability in collision athletes. METHODS: The author surgically treated patients with a diagnosis of traumatic shoulder joint instability and investigated those that had been followed up for >2 years after surgery. RESULTS: Seven shoulders in six collision athletes with a history of traumatic injury were examined. All cases were negative for the general laxity sign and positive for the posterior jerk test; five shoulders showed positive anterior apprehension. Posterior glenoid osseous defects were found in three shoulders, and one shoulder injury involved anterior and posterior osseous lesions. As surgical treatment, one posterior capsulolabral lesion, two posterior osseous lesions, and three combined anterior and posterior capsulolabral lesions were repaired arthroscopically. In a patient with a combined anterior and posterior osseous lesion, the Bristow procedure was perfromed after arthroscopic osseous repair. Patients returned to competition at an average of 6.8 months after surgery. One patient developed anterior subluxation at 7 months, and another exhibited posterior re-dislocation at 8 months after returning to competition. CONCLUSION: Traumatic posterior instability in collision athletes often involves glenoid osseous lesions and is frequently accompanied by anterior apprehension and lesions. Although collision athletes can return to play after arthroscopic repair, such activity is associated with a risk of re-dislocation.


Assuntos
Artroscopia/métodos , Atletas , Traumatismos em Atletas/diagnóstico , Traumatismos em Atletas/cirurgia , Instabilidade Articular/diagnóstico , Instabilidade Articular/cirurgia , Lesões do Ombro , Lesões do Ombro/diagnóstico , Lesões do Ombro/cirurgia , Adulto , Traumatismos em Atletas/fisiopatologia , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Masculino , Amplitude de Movimento Articular , Recidiva , Volta ao Esporte , Lesões do Ombro/fisiopatologia , Articulação do Ombro/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
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